Bactroban ointment is a prescription medication used to treat skin infections such as impetigo, folliculitis, and methicillin-resistant Staphylococcus aureus (MRSA) infections. The active ingredient in Bactroban ointment is mupirocin, which is an antibiotic that works by stopping the growth of bacteria. It is usually applied topically to the affected area of the skin three times a day for up to 10 days. Bactroban ointment is not recommended for use on large areas of the body, and it should not be used for more than 10 days without the advice of a healthcare provider. It is important to follow the instructions of your healthcare provider and to complete the full course of treatment, even if the symptoms improve.