Co-Olesta 40/12.5Mg Tablets contain two active ingredients, namely Amlodipine Besylate (40mg) and Olmesartan Medoxomil (12.5mg). These tablets are used for the treatment of hypertension (high blood pressure) in adults who are already treated with either of the two active ingredients separately or have not responded to monotherapy. The tablets are usually taken orally once daily and should be swallowed whole with water. The dosage and duration of treatment will depend on the individual's medical condition and response to the treatment. It is important to follow the instructions of the prescribing doctor and not to stop or change the dosage without their approval. Possible side effects include dizziness, headache, swelling, and flushing.